Ganciclovir

• Catalog No.: Bio-0291
• CAS Number: 82410-32-0
• M. F.: C9H13N5O4
• M. W.: 255.23062

SYNONYMS

• IUPAC name: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
• IUPAC Traditional name: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
• Synonyms: Cytovene; 2'-Nor-2'-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine

DATABASE IDS

• CAS Number: 82410-32-0

PROPERTIES

• Application(s): Antiviral agent
• Application(s): Active against herpes simplex virus types 1 and 2
• Application(s): Administered (ivn) in treatment of cytomegalovirus
• Mechanism of Action: Inhibitor of viral-DNA-synthesis

REFERENCES

• Ashton, W.T. et al., Biochem. Biophys. Res. Commun., 1982, 108, 1716, (synth, uv, pmr, props)
• Martin, J.C. et al., J. Med. Chem., 1983, 26, 759, (synth, uv, pmr, cmr, props)
• Matthews, T. et al., Rev. Infect. Dis., S490, 1988, 10, (rev)
• Faulds, D. et al., Drugs, 1990, 39, 597, (rev, pharmacol)
• Capparell, E. et al., Ganciclovir Ther. Cytomegalovirus Infect. 1991, (ed. S.A. Spector) Dekker, 1991, 71, (rev)
• Alhede, B. et al., J.O.C., 1991, 56, 2139-2143, (synth, cmr)
• Freie, H.M.P., Med. Klin. (Munich), (Suppl. 1), 1992, 87, 20, (rev)
• Verheyden, J.P.H., Chron. Drug Discovery, 1993, 3, 299, (ganciclovir, rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 546
• Noble, S. et al., Drugs, 1998, 56, 115-146, (rev)
• Boryski, J. et al., Synthesis, 1999, 625-628, (synth, uv)
• Gao, H. et al., Synthesis, 2000, 329-351, (rev)
• McGavin, J.K. et al., Drugs, 2001, 61, 1153-1183, (rev)