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Ganciclovir

Catalog No. Bio-0291 Name InterBioScreen
CAS Number 82410-32-0 Website http://www.ibscreen.com
M. F. C9H13N5O4 Telephone +7 49652 40091
M. W. 255.23062 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 73249

SYNONYMS

IUPAC name
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
IUPAC Traditional name
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one
Synonyms
Cytovene
2'-Nor-2'-deoxyguanosine
9-(1,3-Dihydroxy-2-propoxymethyl)guanine

DATABASE IDS

CAS Number 82410-32-0

PROPERTIES

Application(s) Antiviral agent
Application(s) Active against herpes simplex virus types 1 and 2
Application(s) Administered (ivn) in treatment of cytomegalovirus
Mechanism of Action Inhibitor of viral-DNA-synthesis

DETAILS

REFERENCES

  • Ashton, W.T. et al., Biochem. Biophys. Res. Commun., 1982, 108, 1716, (synth, uv, pmr, props)
  • Martin, J.C. et al., J. Med. Chem., 1983, 26, 759, (synth, uv, pmr, cmr, props)
  • Matthews, T. et al., Rev. Infect. Dis., S490, 1988, 10, (rev)
  • Faulds, D. et al., Drugs, 1990, 39, 597, (rev, pharmacol)
  • Capparell, E. et al., Ganciclovir Ther. Cytomegalovirus Infect. 1991, (ed. S.A. Spector) Dekker, 1991, 71, (rev)
  • Alhede, B. et al., J.O.C., 1991, 56, 2139-2143, (synth, cmr)
  • Freie, H.M.P., Med. Klin. (Munich), (Suppl. 1), 1992, 87, 20, (rev)
  • Verheyden, J.P.H., Chron. Drug Discovery, 1993, 3, 299, (ganciclovir, rev)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 546
  • Noble, S. et al., Drugs, 1998, 56, 115-146, (rev)
  • Boryski, J. et al., Synthesis, 1999, 625-628, (synth, uv)
  • Gao, H. et al., Synthesis, 2000, 329-351, (rev)
  • McGavin, J.K. et al., Drugs, 2001, 61, 1153-1183, (rev)