Tryptanthrine

• Catalog No.: Bio-0284
• CAS Number: 13220-57-0
• M. F.: C15H8N2O2
• M. W.: 248.23622

SYNONYMS

• IUPAC name: 6H,12H-indolo[2,1-b]quinazoline-6,12-dione
• IUPAC Traditional name: 6H,12H-indolo[2,1-b]quinazoline-6,12-dione
• Synonyms: Couroupitine A

DATABASE IDS

• CAS Number: 13220-57-0

PROPERTIES

• Application(s): Antifungal and antimicrobial agent showing specific activity against dermatophytes
• Application(s): Active against Helicobacter pylori
• Biological Source: Isol. from the yeast Candida lipolytica grown in the presence of L-Trytophan. Also from Couroupita guianensis (Lecythidaceae), Isatis indigotica and Polygonum tiucforum
• Mechanism of Action: AhR-Agonist

REFERENCES

• Brufani, M. et al., Experientia, 1971, 27, 1249, (cryst struct, pmr, ms)
• Fedeli, W. et al., J.C.S. Perkin 2, 1974, 1621, (cryst struct)
• Bergman, J. et al., Tet. Lett., 1977, 2625, (struct, synth)
• Karpf, H. et al., Tet. Lett., 1978, 3007, (synth, ir, uv, ms)
• Honda, G. et al., Planta Med., 1979, 37, 172, (props)
• Mitscher, L.A. et al., Heterocycles, 1981, 15, 1017, (synth)
• Capuano, L. et al., Chem. Ber., 1983, 116, 741, (synth)
• Eguchi, S. et al., Heterocycles, 1992, 33, 153, (synth)
• Cornforth, J. et al., J.C.S. Perkin 1, 1996, 2787, (synth)
• Hashimoto, T. et al., Nat. Med. (N.Y.), 1999, 53, 27, (isol, activity)