Gentianine

• Catalog No.: Bio-0278
• CAS Number: 439-89-4
• M. F.: C10H9NO2
• M. W.: 175.18396

SYNONYMS

• IUPAC name: 5-ethenyl-1H,3H,4H-pyrano[3,4-c]pyridin-1-one
• IUPAC Traditional name: 5-ethenyl-1H,3H,4H-pyrano[3,4-c]pyridin-1-one
• Synonyms: 4-(2-Hydroxyethyl)-5-vinylnicotinic lactone; Erythricine

DATABASE IDS

• CAS Number: 439-89-4

PROPERTIES

• Application(s): Antiinflammator
• Application(s): Hypotensive
• Biological Source: Alkaloid from Gentiana kirilowi and very many other Gentiana spp., from several Swertia spp. and several other genera in Gentianaceae. Also found in Strychnos angolensis and other Strychnos spp.
• Mechanism of Action: Suppressor of TNF-alpha and IL-6 production

REFERENCES

• Proskurnina, N.F., J. Gen. Chem. USSR (Engl. Transl.), 1944, 14, 1148; CA, 40, 7213, (isol, struct)
• Govindachari, T.R. et al., J.C.S., 1957, 551; 2725, (isol, struct, uv, synth)
• Lavie, D. et al., Chem. Ind. (London), 1963, 781, (uv, ir, pmr)
• Bailleul, F. et al., Phytochemistry, 1977, 16, 723, (cmr)
• Delaude, C. et al., Bull. Soc. R. Sci. Liege, 1997, 66, 183-286, (occur, Strychnos)