Osthol

• Catalog No.: Bio-0273
• CAS Number: 484-12-8
• M. F.: C15H16O3
• M. W.: 244.28574

SYNONYMS

• IUPAC name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
• IUPAC Traditional name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
• Synonyms: 7-Methoxy-8-prenylcoumarin

DATABASE IDS

• CAS Number: 484-12-8

PROPERTIES

• Application(s): Analeptic
• Biological Source: Isol. from Imperatoria ostruthium, Choisya spp., Seseli sibiricum, Prangos bucharica and Peucedanum hispanicum
• Mechanism of Action: Modulates TRH-evoked responses by interacting with the TRH receptor
• Mechanism of Action: Calcium blocking

REFERENCES

• Hollis, A.F. et al., Aust. J. Chem., 1961, 14, 101, (Osthol hydrochloride)
• Kapoor, S.K. et al., Phytochemistry, 1968, 7, 147, (Osthol)
• Murray, R.D.H. et al., Tetrahedron, 1971, 27, 1247, (synth)
• Bandopadhyay, M. et al., Indian J. Chem., 1974, 12, 23, (synth)
• Raj, K. et al., Indian J. Chem., Sect. B, 1976, 14, 332, (synth)
• Danchul, T.Y. et al., Khim. Prir. Soedin., 1977, 13, 575; Chem. Nat. Compd. (Engl. Transl.), 1977, 13, 479, (Osthol)
• Kumar, R. et al., Phytochemistry, 1978, 17, 2111, (Osthol)
• Murray, R.D.H. et al., The Natural Coumarins, J. Wiley, 1982, (occur)
• Fujioka, T. et al., Chem. Pharm. Bull., 1999, 47, 96-100, (Osthol, pmr, cmr)
• Cai, J.-N. et al., J. Nat. Prod., 2000, 63, 485-488, (Osthol hydrate)