Chrysophanol

• Catalog No.: Bio-0267
• CAS Number: 481-74-3
• M. F.: C15H10O4
• M. W.: 254.2375

SYNONYMS

• IUPAC name: 1,8-dihydroxy-3-methyl-9,10-dihydroanthracene-9,10-dione
• IUPAC Traditional name: 1,8-dihydroxy-3-methyl-9,10-dihydroanthracene-9,10-dione
• Synonyms: Rumicin; Rheic acid; Chrysophanic acid; Archinin; 3-Methylchrysazin

DATABASE IDS

• CAS Number: 481-74-3

PROPERTIES

• Application(s): Antimicrobial
• Application(s): Cathartic agent
• Biological Source: Constit. of Cassia, Rumex, Rheum, Asphodelus and Muehlenbeckia spp., etc. Also isol. from Monilinia fructicola. V. widely distributed
• Mechanism of Action: Inhibitor of phosphoinositide- 3-kinase (PI3K)/AKT
• Mechanism of Action: Monoamine oxidase inhibitor

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 88A, (ir)
• King, F.E. et al., J.C.S., 1952, 4580, (synth)
• Bloom, H. et al., J.C.S., 1959, 178, (ir)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, no. 1254, (occur)
• Labadie, R.P., Pharm. Weekbl., 1972, 107, 535, (occur)
• Rizk, A.M. et al., Phytochemistry, 1972, 11, 2122, (deriv)
• Banville, J. et al., Can. J. Chem., 1974, 52, 80, (synth, uv, pmr)
• Harris, T.M. et al., J.A.C.S., 1976, 98, 6065, (synth)
• Kraus, G.A. et al., J.O.C., 1983, 48, 3439, (synth)
• Kelly, T.R. et al., J.O.C., 1983, 48, 3573, (isol)
• Anderson, J.A. et al., Phytochemistry, 1986, 25, 103, (biosynth)
• Ahmed, S.A. et al., Chem. Comm., 1987, 883, (synth)
• Thomson, W.H., Naturally Occurring Quinones, Recent Advances, Chapman and Hall, 1987, (occur)
• Sassa, T. et al., Agric. Biol. Chem., 1991, 55, 95, (isol)
• Danielsen, K. et al., Magn. Reson. Chem., 1992, 30, 359, (pmr, cmr)
• Schmidt, R.R. et al., Synthesis, 1994, 255, (synth, pmr)
• Schripsema, J. et al., Phytochemistry, 1996, 42, 177, (pmr, struct)