Plumbagin

• Catalog No.: Bio-0244
• CAS Number: 481-42-5
• M. F.: C11H8O3
• M. W.: 188.17942

SYNONYMS

• IUPAC name: 5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione
• IUPAC Traditional name: 5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione
• Synonyms: Ophioxylin

DATABASE IDS

• CAS Number: 481-42-5

PROPERTIES

• Application(s): Exhibits bactericidal
• Application(s): Fungicidal,antimalarial,
• Application(s): tuberculostatic and cardiotonic activity
• Biological Source: Constit. of various Plumbago spp., Dyerophyton africanum, Drosera congolana , many Diospyros spp., roots of Dioncophyllum thollonii, Nepenthe rafflesiana, Aristea ecklonii and other Aristea spp., Sisyrinchium californicum and Sparaxis tricolor
• Mechanism of Action: Suppressor of NF-kB activation, modulator of p65 and 1kB-alpha kinase activation

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 94A, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 909C, (nmr)
• Fieser, L.F. et al., J.A.C.S., 1936, 58, 572-575, (synth)
• Sidhu, G.S. et al., Indian J. Chem., 1968, 6, 681-691, (isol, spectra, deriv)
• Durand, R. et al., Tet. Lett., 1971, 3009-3012, (biosynth)
• Padhye, S.B. et al., J. Magn. Reson., 1974, 16, 150-152, (pmr)
• Ghouse, K.M. et al., Z. Kristallogr., Kristallgeom., Kristallphys., Kristallchem., 1974, 139, 335-336, (cryst struct)
• Padhye, S.B. et al., J. Phys. Chem., 1975, 79, 927-928, (uv)
• Ichihara, A. et al., Agric. Biol. Chem., 1980, 44, 211-213, (synth)
• Kubo, I. et al., Planta Med., (Suppl.), 1980, 185-187, (isol)
• Chandrasekaran, B. et al., J. Biosci., 1981, 3, 395-400, (metab)
• Kubo, I. et al., Agric. Biol. Chem., 1983, 47, 911-913, (activity)
• Wurm, G. et al., Arch. Pharm. (Weinheim, Ger.), 1986, 319, 190-191, (synth)
• Watanabe, M. et al., Chem. Pharm. Bull., 1986, 34, 2810-2820, (synth)
• Sarkaram, A.V.B. et al., Phytochemistry, 1986, 25, 2867-2871, (cmr)
• Vijayalakshmi, J. et al., Acta Cryst. C, 1987, 43, 2375-2377, (cryst struct)
• Kiuchi, F. et al., Shoyakugaku Zasshi, 1989, 43, 283-293, (activity)
• Gujar, G.T., Fitoterapia, 1990, 387-394, (rev, pharmacol, props)
• Mohan, P.S. et al., Indian J. Chem., Sect. B, 1997, 36, 1044-1046, (synth)
• Rama Mohan, H. et al., Indian J. Chem., Sect. B, 1997, 36, 1044-1046, (synth)
• Higa, M. et al., Chem. Pharm. Bull., 1998, 46, 1189-1193, (activity, isol)
• Takeya, T. et al., Chem. Pharm. Bull., 1999, 47, 209-219, (Me ether, Ac, synth, ir, pmr, cmr)
• Munday, R. et al., Planta Med., 2000, 66, 399-402, (activity)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PJH610