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Heliomycin

Catalog No. Bio-0218 Name InterBioScreen
CAS Number 11029-70-220004-62-0 Website http://www.ibscreen.com
M. F. C22H16O6 Telephone +7 49652 40091
M. W. 376.35884 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 179736

SYNONYMS

IUPAC name
2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[13.3.1.05,18.08,17.011,16]nonadeca-1(18),2,4,8,10,12,14,16-octaene-6,19-dione
IUPAC Traditional name
2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[13.3.1.05,18.08,17.011,16]nonadeca-1(18),2,4,8,10,12,14,16-octaene-6,19-dione
Synonyms
Heliomycin
Antibiotic A 3733A
Geliomycin
Croceomycin
Itamycin
Antibiotic 11-98
Antibiotic X 340

DATABASE IDS

CAS Number 11029-70-220004-62-0

PROPERTIES

Application(s) Antibiotic
Application(s) Anti-HIV
Application(s) Shows activity against gram-positive and mycobacteria
Biological Source Constit. of the mycelium of Streptomyces resistomycificius and other Streptomyces spp.
Mechanism of Action RNA polymerase inhibitor
Mechanism of Action HIV Protease Inhibitor

DETAILS

REFERENCES

  • Brockmann, A. et al., Chem. Ber., 1954, 87, 1036, (isol)
  • Rosenbrook, W., J.O.C., 1967, 32, 2924, (struct, uv, nmr)
  • Bailey, N.A. et al., Chem. Comm., 1968, 374, (cryst struct)
  • Brockmann, H. et al., Chem. Ber., 1969, 102, 1224, (struct, ir, uv, nmr)
  • Eckhardt, K. et al., Tetrahedron, 1970, 26, 5875, (struct, ir, uv, nmr)
  • Kingston, J.F. et al., Can. J. Chem., 1977, 55, 785, (synth)
  • Keay, B.A. et al., J.A.C.S., 1982, 104, 4725, (synth)
  • Hfle, G. et al., Annalen, 1983, 835, (isol, biosynth, cmr)
  • Kelly, T.R. et al., J.A.C.S., 1985, 107, 3879, (synth)
  • Arora, S.K., J. Antibiot., 1985, 38, 113, (struct)
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, HAL000