Heliomycin

• Catalog No.: Bio-0218
• CAS Number: 11029-70-220004-62-0
• M. F.: C22H16O6
• M. W.: 376.35884

SYNONYMS

• IUPAC name: 2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[13.3.1.0^5,^1^8.0^8,^1^7.0^1^1,^1^6]nonadeca-1(18),2,4,8,10,12,14,16-octaene-6,19-dione
• IUPAC Traditional name: 2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[13.3.1.0^5,^1^8.0^8,^1^7.0^1^1,^1^6]nonadeca-1(18),2,4,8,10,12,14,16-octaene-6,19-dione
• Synonyms: Heliomycin; Antibiotic A 3733A; Geliomycin; Croceomycin; Itamycin; Antibiotic 11-98; Antibiotic X 340

DATABASE IDS

• CAS Number: 11029-70-220004-62-0

PROPERTIES

• Application(s): Antibiotic
• Application(s): Anti-HIV
• Application(s): Shows activity against gram-positive and mycobacteria
• Biological Source: Constit. of the mycelium of Streptomyces resistomycificius and other Streptomyces spp.
• Mechanism of Action: RNA polymerase inhibitor
• Mechanism of Action: HIV Protease Inhibitor

REFERENCES

• Brockmann, A. et al., Chem. Ber., 1954, 87, 1036, (isol)
• Rosenbrook, W., J.O.C., 1967, 32, 2924, (struct, uv, nmr)
• Bailey, N.A. et al., Chem. Comm., 1968, 374, (cryst struct)
• Brockmann, H. et al., Chem. Ber., 1969, 102, 1224, (struct, ir, uv, nmr)
• Eckhardt, K. et al., Tetrahedron, 1970, 26, 5875, (struct, ir, uv, nmr)
• Kingston, J.F. et al., Can. J. Chem., 1977, 55, 785, (synth)
• Keay, B.A. et al., J.A.C.S., 1982, 104, 4725, (synth)
• Hfle, G. et al., Annalen, 1983, 835, (isol, biosynth, cmr)
• Kelly, T.R. et al., J.A.C.S., 1985, 107, 3879, (synth)
• Arora, S.K., J. Antibiot., 1985, 38, 113, (struct)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, HAL000