Piperine

• Catalog No.: Bio-0217
• CAS Number: 94-62-2495-91-0
• M. F.: C17H19NO3
• M. W.: 285.33766

SYNONYMS

• IUPAC name: (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
• IUPAC Traditional name: (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
• Synonyms: 1-Piperoylpiperidine

DATABASE IDS

• CAS Number: 94-62-2495-91-0

PROPERTIES

• Application(s): Analeptic
• Application(s): Bactericidal agent
• Biological Source: Constit. of pepper (Piper nigrum) and many other Piper spp. (Piperaceae)
• Mechanism of Action: Activator of the heat and acidity sensing TRPV ion channel TRPV1 on nociceptors (pain sensing nerve cells).

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 362C, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1379B, (nmr)
• Rgheimer, L., Ber., 1882, 15, 1390, (synth, Piperine)
• Grewe, R. et al., Chem. Ber., 1970, 103, 3752, (isol, uv, ir, pmr, synth)
• Wenkert, E. et al., J.A.C.S., 1971, 93, 6271, (pmr, cmr, Piperine)
• Grynpas, M. et al., Acta Cryst. B, 1975, 31, 2663, (cryst struct, Piperine)
• DeCleyn, R. et al., Chromatographia, 1975, 8, 342, (isol, uv)
• Tsuboi, S. et al., Tet. Lett., 1979, 1043, (synth, Piperine, Isochavicine)
• Schulze, A. et al., Annalen, 1981, 1725, (synth)
• Kaga, H. et al., Synlett, 1994, 607, (synth, Piperine)
• De Araujo-Junior, J.X. et al., Phytochemistry, 1997, 44, 559, (pmr, cmr, Piperine)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PIV600