Scopoletin

• Catalog No.: Bio-0208
• CAS Number: 92-61-5
• M. F.: C10H8O4
• M. W.: 192.16812

SYNONYMS

• IUPAC name: 7-hydroxy-6-methoxy-2H-chromen-2-one
• IUPAC Traditional name: 7-hydroxy-6-methoxy-2H-chromen-2-one
• Synonyms: Aesculetin 6-methyl ether; Chrysatropic acid; Escopoletin; Gelseminic acid; beta-Methylaesculetin; Buxuletin; Scopoletol; Baogongteng B

DATABASE IDS

• CAS Number: 92-61-5

PROPERTIES

• Application(s): Antitumour agent
• Application(s): Antispasmodic
• Biological Source: Occurs widely in the plant world, for example, the root of Gelsemium sempervirens, Atropa belladonna, Convolvulus scammonia, Ipomoea orizabensis, Prunus serotina, Fabiana imbricata and also Diospyros spp., Peucedanum spp., Heracleum spp., Skimmia spp. Also occurs in the Chinese crude drug Toki (from Angelica acutiloba )
• Mechanism of Action: C (PKC) protein kinase inhibitor

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 324B, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1314B, (nmr)
• Seka, R. et al., Ber., 1931, 64, 909
• Head, F.G.H. et al., J.C.S., 1931, 1241, (synth)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, nos. 1328; 1329, (occur)
• Gonzlez, A.G. et al., An. Quim., 1973, 69, 1013, (pmr)
• Tanaka, S. et al., Arzneim.-Forsch., 1977, 27, 2039, (isol)
• Herath, W.H.M. et al., Phytochemistry, 1978, 17, 1007, (isol)
• Ishibura, N. et al., Z. Naturforsch., C, 1979, 34, 628
• Murray, R.D.H. et al., The Natural Coumarins, J. Wiley, 1982, (occur, rev)
• Abu-Eittah, R.H. et al., Can. J. Chem., 1985, 63, 1173, (uv)
• Koul, S.K. et al., Indian J. Chem., Sect. B, 1987, 26, 574, (synth)
• Udovin, A.D. et al., Khim. Prir. Soedin., 1987, 23, 796; Chem. Nat. Compd. (Engl. Transl.), 1987, 23, 660, (cmr)
• Wollenweber, E. et al., Fitoterapia, 1989, 60, 460, (isol, derivs)
• Mizuno, M. et al., Phytochemistry, 1992, 31, 717, (deriv)
• Hauer, H. et al., Arch. Pharm. (Weinheim, Ger.), 1995, 328, 737, (synth)