Cycloserine

• Catalog No.: Bio-0191
• CAS Number: 68-41-7
• M. F.: C3H6N2O2
• M. W.: 102.09194

SYNONYMS

• IUPAC name: (4R)-4-amino-1,2-oxazolidin-3-one
• IUPAC Traditional name: (4R)-4-amino-1,2-oxazolidin-3-one
• Synonyms: Antibiotic 106-7; Antibiotic Ro 1-9213; Closina; Oxamycin; Antibiotic I 1431; Seromycin; Farmiserina; Micoserina; Orientomycin; Cyclomycin; Oxymycin; Antibiotic E 733A; Antibiotic K 300; Antibiotic NJ 21; Antibiotic PA 94; Antibiotic 5915; Antibiotic 8217; Antibiotic 17452; Orientmycin

DATABASE IDS

• CAS Number: 68-41-7

PROPERTIES

• Application(s): Shows antibiotic activity primarily against mycobacteria
• Application(s): Tuberculostatic
• Biological Source: Prod. by Streptomyces garyphalus, Streptomyces orchidaceus, Streptomyces lavendulae and Streptomyces nagasakiensis
• Mechanism of Action: Inhibits cell-wall-synthesis in: Mycobacterium tuberculosis
• Mechanism of Action: Antagonizes the role of D-alanine in bacterial cell-wall-synthesis
• Mechanism of Action: Susceptible strains of gram-negative bacteria
• Mechanism of Action: Susceptible strains of gram-positive bacteria

REFERENCES

• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 810A; 810D; 811A, (ir)
• Aldrich Library of NMR Spectra, 2nd edn., 1983, 1, 678B; 678C; 678D, (nmr)
• Harned, R.L. et al., Antibiot. Chemother. (Washington, D.C.), 1955, 5, 204, (struct)
• Stammer, C.H. et al., J.A.C.S., 1955, 77, 2344; 2345; 2346; 1957, 79, 3236, (struct, synth, isol, resoln)
• Neuhaus, F.C., Antibiotics (N.Y.), 1967, 1, 40, (rev)
• Milne, G.W.A. et al., Tetrahedron, 1967, 23, 65, (nmr, ms)
• Lamb, J.W., Anal. Profiles Drug Subst., 1972, 1, 53, (rev, synth, anal)
• O'Brien, P., Met. Ions Biol. Syst., 1985, 19, 295, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 107, (synonyms)
• El-Obeid, H.A. et al., Anal. Profiles Drug Subst., 1989, 18, 567, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 156
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CQH000