Diphyllin

• Catalog No.: Bio-0182
• CAS Number: 22055-22-7
• M. F.: C21H16O7
• M. W.: 380.34754

SYNONYMS

• IUPAC name: 9-(2H-1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-1H,3H-naphtho[2,3-c]furan-1-one
• IUPAC Traditional name: 9-(2H-1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-1H,3H-naphtho[2,3-c]furan-1-one

DATABASE IDS

• CAS Number: 22055-22-7

PROPERTIES

• Application(s): Cytotoxin
• Application(s): Regulator of osteoclastic resorption lacunae and bone resorption
• Biological Source: Lignan from roots of Diphylleia grayi, leaves of Cleistanthus collinus, Justicia procumbens and Haplophyllum hispanicum
• Mechanism of Action: Potent V-ATPase inhibitor

REFERENCES

• Horii, Z. et al., Chem. Comm., 1968, 653, (struct)
• Govindachari, T.R. et al., Tetrahedron, 1969, 25, 2815, (isol, struct)
• Okigawa, M. et al., Tetrahedron, 1970, 26, 4301, (isol)
• Stevenson, R. et al., J.O.C., 1971, 36, 3450; 3453, (synth)
• Arnold, B.J. et al., J.C.S. Perkin 1, 1973, 1266, (synth)
• Horii, Z. et al., Chem. Pharm. Bull., 1977, 25, 1803, (synth)
• Anjaneyulu, A.S.R. et al., Indian J. Chem., Sect. B, 1977, 15, 10, (isol, struct)
• Momose, T. et al., Chem. Pharm. Bull., 1978, 26, 3195, (synth)
• Gonzalez, A.G. et al., Planta Med., 1979, 36, 200-203, (Diphyllinins)
• Fukamiya, N. et al., J. Nat. Prod., 1986, 49, 348
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CMV375