Cotinine

• Catalog No.: Bio-0180
• CAS Number: 486-56-6
• M. F.: C10H12N2O
• M. W.: 176.21508

SYNONYMS

• IUPAC name: (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
• IUPAC Traditional name: (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one

DATABASE IDS

• CAS Number: 486-56-6

PROPERTIES

• Application(s): Psychostimulant
• Application(s): Antidepressant
• Application(s): Improves mental function in treating schizophrenia, Alzheimer's and Parkinson's diseases
• Biological Source: Alkaloid from leaf tobacco (Nicotiana tabacum), also detected in Duboisia hopwoodii (Solanaceae)
• Mechanism of Action: Prevents neuron death

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 294C, (nmr)
• Aldrich Library of FT-IR Spectra: Vapor Phase, 1989, 3, 1537C, (ir)
• Pinner, A., Arch. Pharm. (Weinheim, Ger.), 1893, 231, 378, (synth)
• Frankenburg, W.G. et al., J.A.C.S., 1957, 79, 149, (isol, struct, ir)
• Testa, B. et al., Mol. Pharmacol., 1973, 9, 10, (conformn)
• Leete, E. et al., J.O.C., 1976, 41, 3438; 1978, 43, 2860, (synth, ms)
• Tsujino, Y. et al., Agric. Biol. Chem., 1979, 43, 871, (synth)
• Acheson, R.M. et al., J.C.S. Perkin 1, 1980, 2, 579, (synth)
• Nishida, T. et al., Org. Magn. Reson., 1980, 13, 434, (cmr)
• Luanratana, O. et al., Phytochemistry, 1982, 21, 449, (isol)
• Benowitz, N.L. et al., Clin. Pharmacol. Ther. (St. Louis), 1983, 34, 604, (metab)
• Kyerematen, G.A. et al., Life Sci., 1983, 32, 551, (metab)
• Moriarty, R.M. et al., Tet. Lett., 1988, 29, 6913, (()-form, synth)
• Anderson, I.G. et al., Analyst (London), 1991, 116, 691, (gc)
• Sato, T. et al., Heterocycles, 1992, 33, 139, (synth)
• Deutsch, J. et al., J. Chromatogr., 1992, 579, 93, (gc-ms)
• McAdams, S.A. et al., J. Chromatogr., 1993, 615, 148, (gc-ms)
• Keenan, R.M. et al., Clin. Pharmacol. Ther. (St. Louis), 1994, 55, 581, (pharmacol)
• Sato, T. et al., J.C.S. Perkin 1, 1995, 1115, (synth)