Nimodipine

• Catalog No.: Bio-0178
• CAS Number: 66085-59-4
• M. F.: C21H26N2O7
• M. W.: 418.44034

SYNONYMS

• IUPAC name: 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: Admon; Periplum; Kenesil; Calnit; Nimotop

DATABASE IDS

• CAS Number: 66085-59-4

PROPERTIES

• Application(s): Cerebral vasodilator
• Mechanism of Action: Calcium channel blockader
• Mechanism of Action: Blocks intracellular influx of calcium that is thought to be a central to ischaemic neuronal damage.
• Mechanism of Action: Nimodipine binds specifically to L-type voltage-gated calcium channels

REFERENCES

• U.K. Pat., 1979, Bayer, 2 018 134; CA, 92, 220691r, (synth, pharmacol)
• Meyer, H. et al., Arzneim.-Forsch., 1981, 31, 407; 1982, 32, 338; 1983, 33, 106, (synth, pharmacol, enantiomers)
• Ger. Pat., 1981, Bayer, 2 935 451; CA, 95, 42922j, (synth, resoln)
• Schchtele, C. et al., Naunyn-Schmiedeberg's Arch. Pharmacol., 1987, 335, 340, (pharmacol)
• Scriabine, A. et al., Ann. N.Y. Acad. Sci., 1988, 522, 698, (rev, pharmacol)
• Wang, S.D. et al., Acta Cryst. C, 1989, 45, 1748, (cryst struct)
• Langley, M.S. et al., Drugs, 1989, 37, 669, (rev)
• Bar, P.R. et al., J. Neural Trans. Suppl., 1990, 31, (pharmacol, rev)
• Nimodipine, (Eds. Scriabine, A. et al), Springer-Verlag, 1991, (book)
• Wadworth, A.N. et al., Drugs Aging, 1992, 2, 262, (rev)
• Whitfield, P.C. et al., Br. J. Hosp. Med., 1994, 52, 539, (rev)
• Kakarieka, A. et al., J. Neural Trans. Suppl., 1994, 43, 13, (clin trial, rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 8483, (synonyms)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 922
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, NDY700