Nisoldipine

• Catalog No.: Bio-0177
• CAS Number: 63675-72-9
• M. F.: C20H24N2O6
• M. W.: 388.41436

SYNONYMS

• IUPAC name: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: Sular; Nisocor

DATABASE IDS

• CAS Number: 63675-72-9

PROPERTIES

• Application(s): Coronary vasodilator
• Application(s): Antihypertensive agent
• Mechanism of Action: Calcium channel antagonist
• Mechanism of Action: By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum
• Mechanism of Action: inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes.
• Mechanism of Action: The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells,
• Mechanism of Action: causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue,
• Mechanism of Action: decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload

REFERENCES

• Ger. Pat., 1977, 2 549 568; CA, 87, 84831d, (synth, pharmacol)
• Kazda, S. et al., Arzneim.-Forsch., 1980, 30, 2144, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 13022
• Kazda, S. et al., New Drugs Annu.: Cardiovasc. Drugs, 1983, 1, 243, (rev)
• Hugenholtz, P.G. et al., Nisoldipine 1987, Springer-Verlag, Berlin, 1987, (book)
• Ahr, H.J. et al., Arzneim.-Forsch., 1988, 38, 1093; 1099; 1105, (pharmacokinet)
• Friedel, H.A. et al., Drugs, 1988, 36, 682, (rev)
• Fossheim, R. et al., J. Med. Chem., 1988, 31, 300, (cryst struct)
• Mitchell, J. et al., J. Clin. Pharmacol., 1993, 33, 46, (rev)
• Langtry, H.D. et al., Drugs, 1997, 54, 867-884, (rev)