Naftopidil

• Catalog No.: Bio-0174
• CAS Number: 57419-08-3
• M. F.: C24H28N2O3
• M. W.: 392.49072

SYNONYMS

• IUPAC name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol
• IUPAC Traditional name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol
• Synonyms: Avishot; Flivas

DATABASE IDS

• CAS Number: 57419-08-3

PROPERTIES

• Application(s): Antihypertensive agent
• Application(s): Vasodilator, mediates contraction of prostatic smooth muscle
• Application(s): Used for the treatment of dysuria associated with benign prostatic hypertrophy
• Mechanism of Action: Vasodilator
• Mechanism of Action: alpha-1 Adrenoceptor and calcium antagonist

REFERENCES

• Ger. Pat., 1975, Boehringer Mannheim, 2 408 804; CA, 83, 179122e, (synth)
• Drugs of the Future, 1987, 12, 31, (rev)
• Niebch, G. et al., J. Chromatogr., 1990, 534, 247, (hplc)
• Peter, G. et al., Arzneim.-Forsch., 1991, 41, 924, (pharmacokinet)
• Himmel, H.M. et al., J. Cardiovasc. Pharmacol., 1991, 17, 213, (props)
• Kutscher, B. et al., Arch. Pharm. (Weinheim, Ger.), 1993, 326, 803, (metab)
• Himmel, H.M., Cardiovasc. Drug Rev., 1994, 12, 32, (rev)
• Yamada, S. et al., Life Sci., 1994, 54, 1845, (pharmacol)
• Pescalli, N. et al., Pharmacol. Res., 1996, 34, 121
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 914