Olanzapine

• Catalog No.: Bio-0169
• CAS Number: 132539-06-1
• M. F.: C17H20N4S
• M. W.: 312.4325

SYNONYMS

• IUPAC name: 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0^3,^7]tetradeca-1(14),3(7),5,8,10,12-hexaene
• IUPAC Traditional name: 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0^3,^7]tetradeca-1(14),3(7),5,8,10,12-hexaene
• Synonyms: Zalasta; Zolafren; Zyprexa; Zyprexa Zydis; Olzapin

DATABASE IDS

• CAS Number: 132539-06-1

PROPERTIES

• Application(s): Antipsychotic agent
• Application(s): Used in the treatment of schizophrenia and bipolar disorder
• Mechanism of Action: 5HT(2) and dopamine D2 receptor antagonist

REFERENCES

• Eur. Pat., 1991, Lilly, 454 436; CA, 116, 83703u, (synth, pharmacol)
• Moore, N.A. et al., J. Pharmacol. Exp. Ther., 1992, 262, 545, (pharmacol)
• Fulle, R.W. et al., Res. Commun. Chem. Pathol. Pharmacol., 1992, 77, 87, (pharmacol)
• Fulton, B. et al., Drugs, 1997, 53, 281-298, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 683
• Bhana, N. et al., Drugs, 2001, 61, 111-161, (rev)