Dutasteride

• Catalog No.: Bio-0167
• CAS Number: 164656-23-9
• M. F.: C27H30F6N2O2
• M. W.: 528.5297192

SYNONYMS

• IUPAC name: (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-3-ene-14-carboxamide
• IUPAC Traditional name: (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-3-ene-14-carboxamide
• Synonyms: Duagen; Avodart; Dutas; Duprost; Avidart; Avolve; Dutagen

DATABASE IDS

• CAS Number: 164656-23-9

PROPERTIES

• Application(s): Under investigation for treatment of benign prostatic hyperplasia
• Mechanism of Action: 5 alpha reductase inhibitor

REFERENCES

• Bakshi, R.K. et al., J. Med. Chem., 1995, 38, 3189-3192; 1996, 39, 1192, (synth, pharmacol)
• Pat. Coop. Treaty (WIPO), 1995, Glaxo, 95 07 927; CA, 123, 56393f, (synth, pharmacol, cmr)
• Bramson, H.N. et al., J. Pharmacol. Exp. Ther., 1997, 282, 1496-1502, (hplc, pharmacokinet)
• Graul, A. et al., Drugs of the Future, 1999, 24, 246-253