Doxapram Hydrochloride

• Catalog No.: Bio-0166
• CAS Number: 7081-53-0
• M. F.: C24H31ClN2O2
• M. W.: 414.96814

SYNONYMS

• IUPAC name: 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one hydrochloride
• IUPAC Traditional name: 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one hydrochloride

DATABASE IDS

• CAS Number: 7081-53-0

PROPERTIES

• Application(s): Used in intensive care settings to stimulate the respiratory rate
• Salt Data: HCl
• Mechanism of Action: CNS and respiratory stimulant
• Mechanism of Action: Stimulates chemoreceptors in the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem

REFERENCES

• Soma, L.R. et al., Am. J. Vet. Res., 1967, 28, 191, (pharmacol)
• Cale, A.D. et al., J. Med. Chem., 1967, 10, 214, (synth, pharmacol)
• Salim, E.F. et al., J. Pharm. Sci., 1967, 56, 748, (props)
• Siek, T.J., J. Forensic Sci., 1974, 19, 193, (uv)
• Franz, D.N. et al., Pharmacol. Basis Ther., 5th edn., 1975, 359, (rev)
• Robson, R.H. et al., Br. J. Clin. Pharmacol., 1979, 7, 81, (metab)
• Clements, J.A. et al., Eur. J. Clin. Pharmacol., 1979, 16, 411, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1225
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ENL100; SLU000