Trimebutine

• Catalog No.: Bio-0163
• CAS Number: 39133-31-8
• M. F.: C22H29NO5
• M. W.: 387.46936

SYNONYMS

• IUPAC name: 2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate
• IUPAC Traditional name: 2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate
• Synonyms: Cerekinon; Spabucol; Mebutin; Digerent

DATABASE IDS

• CAS Number: 39133-31-8

PROPERTIES

• Application(s): Antispasmodic agent
• Mechanism of Action: The actions of trimebutine on the gastrointestinal tract are mediated via
• Mechanism of Action: (i) an agonist effect on peripheral mu, kappa and delta opiate receptors and
• Mechanism of Action: (ii) release of gastrointestinal peptides such as motilin and modulation of the release of other peptides, including vasoactive intestinal peptide, gastrin and glucagon

REFERENCES

• U.K. Pat., 1972, 1 342 547; CA, 78, 58079j, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6665
• Fraitag, B. et al., Gastroenterol. Clin. Biol., 1992, 16, 413, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1423
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TKU650; TKU675