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Metformin hydrochloride

Catalog No. Bio-0158 Name InterBioScreen
CAS Number 1115-70-4 Website http://www.ibscreen.com
M. F. C4H12ClN5 Telephone +7 49652 40091
M. W. 165.62458 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 72826

SYNONYMS

IUPAC name
1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
IUPAC Traditional name
1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
Synonyms
Glucophege
Fluamine
Diabetase
Glucamet
Stagid
Diabetosan
Orabet
Gliguamid
Glucinan

DATABASE IDS

CAS Number 1115-70-4

PROPERTIES

Application(s) Oral hypoglycaemic agent
Application(s) Used for treatment of type 2 diabetes
Salt Data HCl
Mechanism of Action Stimulator of hepatic enzyme AMP-activated protein kinase (AMPK)

DETAILS

REFERENCES

  • Aldrich Library of Infrared Spectra, 3rd edn., 1981, 487G, (ir)
  • Werner, E.A. et al., J.C.S., 1922, 1790, (synth)
  • Shapiro, S.L. et al., J.A.C.S., 1959, 81, 3728, (synth, pharmacol)
  • Ger. Pat., 1969, 1 900 772; CA, 72, 43230d, (synth, deriv)
  • Beckmann, R. et al., CA, 1970, 72, 30102p, (metab)
  • Nandi, S.D., Tetrahedron, 1972, 28, 845, (uv, deriv)
  • Hermann, L.S., Diabetes/Metab. Rev., 1979, 5, 233, (rev)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 247, (synonyms)
  • Grigorescu, F. et al., Diabete Metab., 1991, 17, 146, (biochem)
  • Bailey, C.J., Gen. Pharmacol., 1993, 24, 1299, (rev)
  • Dunn, C.J. et al., Drugs, 1995, 49, 721, (rev)
  • Scheen, A.J., Clin. Pharmacokinet., 1996, 30, 359, (rev, pharmacokinet)
  • Bretnall, A.E. et al., Anal. Profiles Drug Subst., 1998, 25, 243-293, (rev, pharmacol)
  • Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 330
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DQR600; DQR800