Zafirlukast

• Catalog No.: Bio-0152
• CAS Number: 107753-78-6
• M. F.: C31H33N3O6S
• M. W.: 575.67522

SYNONYMS

• IUPAC name: cyclopentyl N-[3-({2-methoxy-4-[(2-methylbenzenesulfonyl)carbamoyl]phenyl}methyl)-1-methyl-1H-indol-5-yl]carbamate
• IUPAC Traditional name: cyclopentyl N-[3-({2-methoxy-4-[(2-methylbenzenesulfonyl)carbamoyl]phenyl}methyl)-1-methyl-1H-indol-5-yl]carbamate
• Synonyms: Accolate

DATABASE IDS

• CAS Number: 107753-78-6

PROPERTIES

• Application(s): Antiasthmatic agent
• Mechanism of Action: Potent leukotriene D4 receptor antagonist (LTRA)

REFERENCES

• Eur. Pat., 1986, ICI, 199 543; CA, 106, 176163b, (synth, pharmacol)
• Dahlen, S.E. et al., Adv. Prostaglandin, Thromboxane, Leukotriene Res., 1990, 21, 461, (pharmacol)
• Krell, R.D. et al., Am. Rev. Respir. Dis., 1990, 141, 978, (rev)
• Matassa, V.G. et al., J. Med. Chem., 1990, 33, 1781, (synth, pharmacol)
• Taylor, I.K. et al., Lancet, 1991, 1, 690, (clin trial)
• Adkins, J.C. et al., Drugs, 1998, 55, 121-144, (pharmacol, rev)
• Chung, K.F. et al., Drugs of Today (Barcelona), 1998, 34, 375-388, (rev, pharmacol)
• Dunn, C.J. et al., Drugs, 2001, 61, 285-315, (rev)