Temozolomide

• Catalog No.: Bio-0147
• CAS Number: 85622-93-1
• M. F.: C6H6N6O2
• M. W.: 194.15084

SYNONYMS

• IUPAC name: 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
• IUPAC Traditional name: 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
• Synonyms: Temodar; Temodal; Methazolastone

DATABASE IDS

• CAS Number: 85622-93-1

PROPERTIES

• Application(s): Antineoplastic agent
• Application(s): Used for the treatment of glioblastoma multiforme
• Mechanism of Action: Alkylating agent

REFERENCES

• U.K. Pat., 1983, May and Baker, 2 104 522; CA, 98, 198285m, (synth)
• Stevens, M.F.G. et al., J. Med. Chem., 1984, 27, 196, (synth, ir, pmr)
• Tisdale, M.J., Br. J. Cancer, 1985, 52, 789, (pharmacol)
• Bull, V.L. et al., Biochem. Pharmacol., 1987, 36, 3215, (pharmacol)
• Stevens, M.F.G. et al., Cancer Res., 1987, 47, 5846, (synth, pharmacol, pharmacokinet, pmr)
• Tsang, L.L.H. et al., Cancer Chemother. Pharmacol., 1990, 26, 429, (metab)
• Newlands, E.S. et al., Br. J. Cancer, 1992, 65, 287, (clin trial)
• Lowe, P.R. et al., J. Med. Chem., 1992, 35, 3377, (cryst struct)
• Denny, B.J. et al., Biochemistry, 1994, 33, 9045, (pmr)
• Wang, Y. et al., Chem. Comm., 1994, 1687-1688, (synth)
• Wheelhouse, R.T. et al., J.C.S. Perkin 1, 1995, 249, (cmr, N-15 nmr)
• Newlands, E.S. et al., Cancer Treat. Rev., 1997, 23, 35
• Wang, Y. et al., J.O.C., 1997, 62, 7288-7294, (synth)
• Hvizdos, K.V. et al., CNS Drugs, 1999, 12, 237, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 565