Raltitrexed

• Catalog No.: Bio-0142
• CAS Number: 112887-68-0
• M. F.: C21H22N4O6S
• M. W.: 458.48758

SYNONYMS

• IUPAC name: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid
• IUPAC Traditional name: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid
• Synonyms: Tomudex

DATABASE IDS

• CAS Number: 112887-68-0

PROPERTIES

• Application(s): Antineoplastic agent
• Mechanism of Action: Thymidylate synthase inhibitor

REFERENCES

• Eur. Pat., 1987, ICI, 239 362; CA, 108, 205094d, (synth)
• Jackman, A.L. et al., Cancer Res., 1991, 51, 5579, (pharmacol)
• Marsham, P.R. et al., J. Med. Chem., 1991, 34, 1594, (synth, pmr, ms, pharmacol)
• Keyomarsi, K. et al., J. Biol. Chem., 1993, 268, 15142, (pharmacol)
• Marsham, P.R., J. Het. Chem., 1994, 31, 603, (rev)
• Harrap, K.R., Cancer Res., 1995, 55, 2761, (pharmacol, rev)
• Gunasekara, N.S. et al., Drugs, 1998, 55, 423-435, (rev)