Proxymetacaine Hydrochloride

• Catalog No.: Bio-0140
• CAS Number: 5875-06-9
• M. F.: C16H27ClN2O3
• M. W.: 330.85018

SYNONYMS

• IUPAC name: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
• IUPAC Traditional name: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
• Synonyms: Alcaine; Opthaine; Proparacaine hydrochloride

DATABASE IDS

• CAS Number: 5875-06-9

PROPERTIES

• Mechanism of Action: However, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane.
• Mechanism of Action: Proparacaine may alter epithelial sodium channels through interaction with channel protein residues.
• Mechanism of Action: This limitation prevents the fundamental change necessary for the generation of the action potential.
• Mechanism of Action: The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown
• Application(s): Local anaesthetic (esp. ophthalmic)
• Salt Data: HCl

REFERENCES

• McIntyre, A.R. et al., J. Pharmacol. Exp. Ther., 1938, 63, 369, (pharmacol)
• Clinton, R.O. et al., J.A.C.S., 1952, 74, 592, (synth)
• Whigan, D.B., Anal. Profiles Drug Subst., 1977, 6, 423, (rev, synth, metab)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 4191
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1017