Pimobendan

• Catalog No.: Bio-0139
• CAS Number: 74150-27-9
• M. F.: C19H18N4O2
• M. W.: 334.37182

SYNONYMS

• IUPAC name: (4R)-6-[2-(4-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]-4-methyl-2,3,4,5-tetrahydropyridazin-3-one
• IUPAC Traditional name: (4R)-6-[2-(4-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]-4-methyl-2,3,4,5-tetrahydropyridazin-3-one
• Synonyms: Acardi; Acordi

DATABASE IDS

• CAS Number: 74150-27-9

PROPERTIES

• Application(s): Shows positive inotropic and vasodilatory activity
• Application(s): Used in the treatment of congestive heart failure
• Mechanism of Action: Vasodilator
• Mechanism of Action: Partial phosphodiesterase (type III) inhibitor

REFERENCES

• Ger. Pat., 1980, Dr Karl Thomae, 2 837 161; CA, 93, 46705g, (synth, pharmacol)
• van Meel, J.C.A., Arzneim.-Forsch., 1985, 35, 284; 1995, 45, 136, (pharmacol)
• Verdouw, P.D. et al., Eur. J. Pharmacol., 1986, 126, 121, (pharmacol)
• Duncker, D.J. et al., Br. J. Pharmacol., 1987, 91, 609, (pharmacol)
• Chu, K.-M. et al., J. Chromatogr. Sci., 1992, 30, 171, (hplc, sepn)
• Asakura, M. et al., J. Chromatogr., 1993, 614, 135, (hplc, sepn)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 672
• Fitton, A. et al., Drugs Aging, 1994, 4, 417, (rev)
• Remme, W.J. et al., J. Cardiovasc. Pharmacol., 1994, 24, 730, (pharmacol, human)