Palonosetron Hydrochloride

• Catalog No.: Bio-0138
• CAS Number: 135729-75-8
• M. F.: C19H25ClN2O
• M. W.: 332.8676

SYNONYMS

• IUPAC name: (5S)-3-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.0^5,^1^3]trideca-1(12),9(13),10-trien-2-one hydrochloride
• IUPAC Traditional name: (5S)-3-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.0^5,^1^3]trideca-1(12),9(13),10-trien-2-one hydrochloride

DATABASE IDS

• CAS Number: 135729-75-8

PROPERTIES

• Application(s): Antiemetic used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)
• Salt Data: HCl
• Mechanism of Action: 5HT(3) receptor antagonist

REFERENCES

• Eur. Pat., 1991, Syntex, 430 190; CA, 115, 114377b, (synth, pharmacol)
• Costall, B. et al., Eur. J. Pharmacol., 1993, 234, 91, (pharmacol)
• Clark, R.D. et al., J. Med. Chem., 1993, 36, 2645-2657, (synth, pharmacol, pmr, cryst struct)
• Wong, E.H.F. et al., J. Neurochem., 1993, 60, 921; 61, 1927, (pharmacol)
• Eglen, R.M. et al., J. Pharmacol. Exp. Ther., 1993, 266, 535, (pharmacol)
• Wong, E.H.F. et al., Br. J. Pharmacol., 1995, 114, 851-859; 860-866, (pharmacol)
• Graul, A. et al., Drugs of the Future, 1996, 21, 906-910, (rev, synth, pharmacol)
• Kowalczyk, B.A. et al., Synthesis, 1996, 816-818; 2000, 1113-1116, (synth, ir, pmr, cmr)
• Kowalczyk, B.A. et al., Org. Process Res. Dev., 1997, 1, 117-120, (synth)