Home > Compound List > Product Information
Mitoxantrone Hydrochloride_Molecular_structure_CAS_70476-82-3)
Click picture or here to close

Mitoxantrone Hydrochloride

Catalog No. Bio-0135 Name InterBioScreen
CAS Number 70476-82-3 Website http://www.ibscreen.com
M. F. C22H29ClN4O6 Telephone +7 49652 40091
M. W. 480.94186 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 179717

SYNONYMS

IUPAC name
1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione hydrochloride
IUPAC Traditional name
1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione hydrochloride
Synonyms
Novantron
Refador
Novatrone
Novantrone
Metrisone
Misostrol

DATABASE IDS

CAS Number 70476-82-3

PROPERTIES

Application(s) Antineoplastic agent against
Application(s) metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma
Salt Data HCl
Mechanism of Action DNA intercalator

DETAILS

REFERENCES

  • Zee-Cheng, R.K.Y. et al., J. Med. Chem., 1978, 21, 291; 1979, 22, 501, (synth, uv, pharmacol)
  • Murdock, K.C. et al., J. Med. Chem., 1979, 22, 1024, (synth, pharmacol)
  • Taylor, R.F. et al., J. Chromatogr., 1980, 187, 212, (hplc)
  • Henderson, B.M. et al., Cancer Treat. Rep., 1982, 66, 1139, (tox)
  • Beijnen, J.H. et al., Anal. Profiles Drug Subst., 1988, 17, 221, (rev)
  • Koeller, J. et al., Clin. Pharm., 1988, 7, 574, (rev, pharmacol)
  • Ehninger, G. et al., Clin. Pharmacokinet., 1990, 18, 365, (rev, pharmacokinet)
  • Faulds, D. et al., Drugs, 1991, 41, 400, (rev)
  • Textbook of Adverse Drug Reactions, 4th edn., (ed. Davies, D.M.), Oxford University Press, 1991, (tox)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 494
  • Catalin, J. et al., Biomed. Chromatogr., 1994, 8, 37, (hplc)
  • Panousis, C. et al., Nucleic Acids Res., 1994, 22, 1342, (pharmacol)
  • Venitt, S. et al., J. Med. Chem., 1998, 41, 3748-3752, (pharmacol)
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MQY090; MQY100