Megestrol Acetate

• Catalog No.: Bio-0133
• CAS Number: 595-33-5
• M. F.: C24H32O4
• M. W.: 384.50848

SYNONYMS

• IUPAC name: (2R,10R,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-6,8-dien-14-yl acetate
• IUPAC Traditional name: (2R,10R,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-6,8-dien-14-yl acetate

DATABASE IDS

• CAS Number: 595-33-5

PROPERTIES

• Application(s): Oral contraceptive
• Application(s): Antineoplastic agent
• Application(s): against carcinoma of the breast and endometrium
• Mechanism of Action: The precise mechanism by which megestrol acetate produces effects in anorexia and cachexia is unknown at the present time
• Mechanism of Action: The biochemical mechanism of progestin antitumour activity is not well but may involve interaction with progesterone and glucocorticoid receptors, androgenic properties
• Mechanism of Action: Also has direct cytotoxic effects on breast cancer cells in tissue culture and suppresses luteinising hormone release from the pituitary

REFERENCES

• Ringold, M.J. et al., J.A.C.S., 1959, 81, 3712, (synth)
• Ellis, B. et al., J.C.S., 1960, 2828, (synth)
• Elce, J.S. et al., Biochem. J., 1967, 104, 58P
• Cooper, J.M. et al., Steroids, 1968, 11, 133
• Annen, K. et al., Annalen, 1983, 712, (deriv)
• Ni, Y. et al., CA, 1984, 101, 23805, (deriv)
• Guo, Z. et al., CA, 1985, 103, 54356, (deriv)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7162, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1187
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VTF000