Loxoprofen Sodium

• Catalog No.: Bio-0131
• CAS Number: 80382-23-6
• M. F.: C15H17NaO3
• M. W.: 268.28345

SYNONYMS

• IUPAC name: sodium (2R)-2-(4-{[(1S)-2-oxocyclopentyl]methyl}phenyl)propanoate
• IUPAC Traditional name: sodium (2R)-2-(4-{[(1S)-2-oxocyclopentyl]methyl}phenyl)propanoate
• Synonyms: Loxonin

DATABASE IDS

• CAS Number: 80382-23-6

PROPERTIES

• Application(s): Analgesic
• Application(s): Non-steroidal antiinflammatory agent
• Salt Data: Na+
• Mechanism of Action: Non-selective cyclooxygenase inhibitor
• Mechanism of Action: Works by reducing the synthesis of prostaglandins from arachidonic acid

REFERENCES

• Ger. Pat., 1978, Sankyo, 2 814 556; CA, 90, 22616r, (synth, pharmacol)
• Tanaka, Y. et al., Chem. Pharm. Bull., 1983, 31, 3656, (metab)
• Terada, A. et al., J. Med. Chem., 1984, 27, 212, (synth)
• Hata, T. et al., Bull. Chem. Soc. Jpn., 1987, 60, 3535, (cryst struct)
• Naganuma, H. et al., J. Chromatogr., 1990, 530, 387, (hplc)
• Sugimoto, M. et al., Biochem. Pharmacol., 1991, 42, 2363, (pharmacol)
• Takasaki, W. et al., Chirality, 1992, 4, 308, (metab)
• Toshimasa, T. et al., J. Chromatogr., 1992, 627, 75, (hplc)
• Watanabe, T. et al., J. Toxicol. Clin. Toxicol., 1993, 31, 333, (tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 22
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, LII300