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Ifosfamide

Catalog No. Bio-0128 Name InterBioScreen
CAS Number 66849-34-1 Website http://www.ibscreen.com
M. F. C7H15Cl2N2O2P Telephone +7 49652 40091
M. W. 261.085961 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 1052

SYNONYMS

IUPAC name
(2S)-3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one
IUPAC Traditional name
(2S)-3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one
Synonyms
Dexifosfamide

DATABASE IDS

CAS Number 66849-34-1

PROPERTIES

Application(s) Antileukaemic
Application(s) Antineoplastic
Application(s) Immunosuppressant
Mechanism of Action Alkylating agent in cancer therapy

DETAILS

REFERENCES

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  • Perales, A. et al., Acta Cryst. B, 1977, 33, 1935, (cryst struct)
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  • Kinas, R.W. et al., Bull. Acad. Pol. Sci., Ser. Sci. Chim., 1978, 26, 39, (resoln)
  • Pankiewicz, K. et al., J.A.C.S., 1979, 101, 7712, (config)
  • Ludeman, S.M. et al., J.O.C., 1979, 44, 1163, (synth)
  • Wroblewski, A.E. et al., Inorg. Chem., 1980, 19, 3713, (complexes, resoln)
  • IARC Monog., 1981, 26, 237; Suppl. 7, 65, (rev, tox)
  • Su, C.N. et al., J.A.C.S., 1982, 104, 7343, (cd)
  • Misiura, K. et al., J. Med. Chem., 1983, 26, 674, (metab)
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  • Buess, M.L. et al., Org. Magn. Reson., 1984, 22, 67, (nqr)
  • Brade, W.P. et al., Cancer Treat. Rep., 1985, 12, 1, (pharmacol, tox, use, rev)
  • Anticancer Drug Research. Lectures and Symposia 14th Int. Cancer Congress, Budapest, (ed., Lapis, K. et al), 1986, 9, 127; 133; 139; 155; 171; 177, (rev)
  • Kleinrok, Z. et al., Arch. Immunol. Ther. Exp., 1986, 34, 293, (pharmacol, isom)
  • Kupfer, A. et al., Lancet, 1990, 335, 1461, (metab)
  • Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 483
  • Gilard, V. et al., J. Med. Chem., 1999, 42, 2542-2560, (pharmacol, metab)
  • Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, IMH000