Ibudilast

• Catalog No.: Bio-0127
• CAS Number: 50847-11-5
• M. F.: C14H18N2O
• M. W.: 230.30552

SYNONYMS

• IUPAC name: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
• IUPAC Traditional name: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
• Synonyms: Ketas

DATABASE IDS

• CAS Number: 50847-11-5

PROPERTIES

• Application(s): Antiallergic
• Application(s): Cerebral vasodilator
• Application(s): Bronchodilator
• Application(s): Neuroprotective
• Mechanism of Action: Lowers Ca 2+ deposition in soft tissues
• Mechanism of Action: Vasodilator
• Mechanism of Action: Bronchodilator
• Mechanism of Action: Phosphodiesterase inhibitor

REFERENCES

• Ger. Pat., 1973, Kyorin Pharm, 2 315 801; CA, 80, 14923s, (synth)
• Japan. Pat., 1977, Kyorin Pharm, 77 14 799; CA, 87, 53282w, (synth, pharmacol)
• Nagai, H. et al., Jpn. J. Pharmacol., 1983, 33, 1215, (pharmacol)
• Mue, S. et al., Arch. Int. Pharmacodyn. Ther., 1986, 283, 153, (pharmacol)
• Izumi, Y. et al., Arzneim.-Forsch., 1990, 40, 1300
• Yasui, M. et al., J. Int. Med. Res., 1990, 18, 415, (pharmacol)
• Ohashi, M. et al., Int. Arch. Allergy Appl. Immunol., 1993, 101, 288, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1140
• Souness, J.E. et al., Br. J. Pharmacol., 1994, 111, 1081, (pharmacol)