Fluvastatin Sodium

• Catalog No.: Bio-0125
• CAS Number: 93957-55-2
• M. F.: C24H25FNNaO4
• M. W.: 433.4477732

SYNONYMS

• IUPAC name: sodium (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• IUPAC Traditional name: sodium (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• Synonyms: Lipaxan; Lymetel; Locol; Primesin; Canef; Cranoc; Fluindostatin; Fractal; Lescol; Vastin

DATABASE IDS

• CAS Number: 93957-55-2

PROPERTIES

• Application(s): Used as an antihyperlipidaemic agent to treat hypercholesterolemia and to prevent cardiovascular disease
• Salt Data: Na+
• Mechanism of Action: Potent HMG-CoA reductase inhibitor

REFERENCES

• Eur. Pat., 1987, Sandoz, 244 364; CA, 108, 131038q, (synth, pharmacol)
• Tse, F.L.S. et al., Biopharm. Drug Dispos., 1990, 11, 519, (metab)
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• Tse, F.L.S. et al., J. Clin. Pharmacol., 1992, 32, 630, (pharmacokinet, human)
• Dain, J.G. et al., Drug Metab. Dispos., 1993, 21, 567, (metab, human)
• Kalafsky, G. et al., J. Chromatogr., 1993, 614, 307, (hplc)
• Brown, W.V., Am. J. Cardiol., 1994, 73, 1D; 12D; 18D, (rev)
• Shiomi, M. et al., Arzneim.-Forsch., 1994, 44, 1154, (pharmacol)
• Robison, R.L. et al., Fundam. Appl. Toxicol., 1994, 23, 9, (tox)
• Plosker, G.L. et al., Drugs, 1996, 51, 433, (rev)
• Drugs of Today (Barcelona), Suppl. A, (Fluvastatin), 1996, 32, (rev, pharmacol, pharmacokinet)
• Langtry, H.D. et al., Drugs, 1999, 57, 583-606, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1273