Zoledronic Acid

• Catalog No.: Bio-0112
• CAS Number: 118072-93-8
• M. F.: C5H10N2O7P2
• M. W.: 272.089622

SYNONYMS

• IUPAC name: [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid
• IUPAC Traditional name: [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid
• Synonyms: Zometa

DATABASE IDS

• CAS Number: 118072-93-8

PROPERTIES

• Application(s): Prevents skeletal fractures in patients with multiple myeloma and prostate cancer
• Mechanism of Action: Bone resorption inhibitor
• Mechanism of Action: Calcium regulator
• Mechanism of Action: Human gamma-lambda T cells activator

REFERENCES

• U.S. Pat., 1990, Ciba-Geigy, 4 939 130; CA, 114, 62355a, (synth, pharmacol)
• Green, J.R. et al., J. Bone Min. Res., 1994, 9, 745, (pharmacol)
• Sorbera, L.A. et al., Drugs of the Future, 2000, 25, 259-268, (rev)
• Berenson, J.R. et al., Cancer (Philadelphia), 2001, 91, 144-154, (pharmacol)
• Cheer, S.M. et al., Drugs, 2001, 61, 799-805, (rev)
• Dunford, J.E. et al., J. Pharmacol. Exp. Ther., 2001, 296, 235-242, (pharmacol)