Venlafaxine hydrochloride

• Catalog No.: Bio-0110
• CAS Number: 99300-78-4
• M. F.: C17H28ClNO2
• M. W.: 313.86272

SYNONYMS

• IUPAC name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride
• IUPAC Traditional name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride

DATABASE IDS

• CAS Number: 99300-78-4

PROPERTIES

• Application(s): Antidepressant for the treatment of clinical depression and anxiety disorders
• Salt Data: HCl
• Mechanism of Action: 5HT Uptake inhibitor
• Mechanism of Action: Serotonin-norepinephrine reuptake inhibitor (SNRI)

REFERENCES

• Eur. Pat., 1984, American Home Products, 112 669; CA, 102, 5895e, (pmr, synth, pharmacol)
• Muth, E.A. et al., Biochem. Pharmacol., 1986, 35, 4493, (pharmacol)
• Fabre, L.F. et al., Curr. Ther. Res., 1987, 42, 901, (adverse effects)
• Yardley, J.P. et al., J. Med. Chem., 1990, 33, 2899, (synth, activity)
• Klamerus, K.J. et al., J. Clin. Pharmacol., 1992, 32, 716, (pharmacokinet)
• Phase III Drug Prof., 1993, 3, 16, (rev)
• Hicks, D.R. et al., Ther. Drug Monit., 1994, 16, 100, (hplc)
• Howell, S.R. et al., Xenobiotica, 1994, 24, 315, (pharmacokinet)
• Holliday, S.M. et al., Drugs, 1995, 49, 280, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 311