Trimetazidine Dihydrochloride

• Catalog No.: Bio-0106
• CAS Number: 13171-25-0
• M. F.: C14H24Cl2N2O3
• M. W.: 339.25796

SYNONYMS

• IUPAC name: 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
• IUPAC Traditional name: 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
• Synonyms: Yosimilon; Vastarel; Preductal; Kyurinett

DATABASE IDS

• CAS Number: 13171-25-0

PROPERTIES

• Application(s): Antiischaemic agent used for the treatment of angina
• Application(s): Potential agent for treatment of cyclosporin A-induced nephrotoxicity
• Salt Data: 2 HCl
• Mechanism of Action: Inhibitor of b oxidation of fatty acid in blood vessles

REFERENCES

• Fr. Pat., 1961, May and Baker, M191; CA, 58, 3442, (synth)
• Fujita, Y., Jpn. J. Pharmacol., 1967, 17, 19, (pharmacol)
• Japan. Pat., 1973, 73 32 889; CA, 79, 32098k, (synth)
• Courte, S. et al., J. Chromatogr., 1981, 224, 162, (hplc)
• Asano, M. et al., Jpn. J. Pharmacol., 1983, 33, 891, (pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3334
• Harpey, C. et al., Cardiovasc. Drug Rev., 1989, 6, 292, (pharmacol, tox, rev)
• Fay, L. et al., J. Chromatogr., 1989, 490, 198, (gc-ms)
• Maseri, A. et al., Am. J. Cardiol., 1995, 76, 1B, (rev, pharmacol, use)
• Vedrinne, C. et al., J. Cardiovasc. Pharmacol., 1996, 28, 500, (pharmacol)
• Salducci, M.D. et al., J. Pharmacol. Exp. Ther., 1996, 277, 417, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 959
• Jackson, P.J. et al., Xenobiotica, 1996, 26, 221, (metab)
• Albengres, E. et al., Cardiovasc. Drug Rev., 1998, 16, 359-390
• McClellan, K.J. et al., Drugs, 1999, 58, 143-157
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, YCJ200