Sildenafil Citrate

• Catalog No.: Bio-0099
• CAS Number: 171599-83-0
• M. F.: C27H36N6O11S
• M. W.: 652.67334

SYNONYMS

• IUPAC name: 2-hydroxypropane-1,2,3-tricarboxylic acid; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
• IUPAC Traditional name: 2-hydroxypropane-1,2,3-tricarboxylic acid; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
• Synonyms: Viagra; Revatio

DATABASE IDS

• CAS Number: 171599-83-0

PROPERTIES

• Application(s): Used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH)
• Salt Data: Citrate
• Mechanism of Action: Vasodilator
• Mechanism of Action: Selective inhibitor of cyclic GMP specific phosphodiesterase (Type V)

REFERENCES

• Eur. Pat., 1992, Pfizer, 463 756; CA, 116, 255626q, (synth, pharmacol)
• Terrett, N.K. et al., Bioorg. Med. Chem. Lett., 1996, 6, 1819-1824, (sildenafil citrate)
• Boolell, M. et al., Br. J. Urol., 1996, 78, 257-261, (pharmacol)
• Martel, A.M. et al., Drugs of the Future, 1997, 22, 138-143, (synth, pharmacol)
• Cooper, J.D.H. et al., J. Chromatogr., B: Biomed. Appl., 1997, 701, 87-95, (hplc)
• Morales, A. et al., Int. J. Impot. Res., 1998, 10, 69-74, (use)
• Ballard, S.A. et al., J. Urol. (Baltimore), 1998, 159, 2164-2171; 160, 242-246, (pharmacol)
• Chuang, A.T. et al., J. Urol. (Baltimore), 1998, 160, 257-261, (pharmacol)
• Palmer, E., Chem. Br., 1999, 24-26, (rev)
• Cheitlin, M.D. et al., Circulation, 1999, 99, 168-177
• Langtry, H.D. et al., Drugs, 1999, 57, 967-989
• Noss, M.B. et al., Drugs of Today (Barcelona), 1999, 35, 211-217
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1629
• Dale, D.J. et al., Org. Process Res. Dev., 2000, 4, 17-22, (synth)