Rofecoxib

• Catalog No.: Bio-0094
• CAS Number: 162011-90-7
• M. F.: C17H14O4S
• M. W.: 314.35566

SYNONYMS

• IUPAC name: 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
• IUPAC Traditional name: 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
• Synonyms: Ceoxx; Ceeoxx; Vioxx

DATABASE IDS

• CAS Number: 162011-90-7

PROPERTIES

• Application(s): Nonsteroidal anti-inflammatory drug (NSAID)
• Mechanism of Action: Cyclooxygenase-2 inhibitor

REFERENCES

• Pat. Coop. Treaty (WIPO), 1995, Merck Frosst, 95 00 501; CA, 124, 55954y, (Rofecoxib, synth, pharmacol)
• Sorbera, L.A. et al., Drugs of the Future, 1998, 23, 1287-1296; 1999, 24, 1374, (rev)
• Ehrich, E.W. et al., Clin. Pharmacol. Ther. (St. Louis), 1999, 65, 336-347, (pharmacol)
• Fung, H.B. et al., Clin. Ther., 1999, 21, 1131
• Scott, L.J. et al., Drugs, 1999, 58, 499-505, (rev)
• Van Ryn, J. et al., Inflammation Res., 1999, 48, 247-254, (rev)
• Jackson, L.M. et al., Drugs, 2000, 59, 1207-1212, (rev)
• Matheson, A.J. et al., Drugs, 2001, 61, 833-865, (rev)
• Schwartz, J.I. et al., J. Clin. Pharmacol., 2001, 41, 107-112, (pharmacokinet)