Riluzole

• Catalog No.: Bio-0090
• CAS Number: 1744-22-5
• M. F.: C8H5F3N2OS
• M. W.: 234.1983096

SYNONYMS

• IUPAC name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
• IUPAC Traditional name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
• Synonyms: Rilutek

DATABASE IDS

• CAS Number: 1744-22-5

PROPERTIES

• Application(s): Anticonvulsant, antiepileptic agent
• Application(s): Used in treatment of amyotrophic lateral sclerosis
• Mechanism of Action: Sodium channel blockade
• Mechanism of Action: High-voltage calcium channel blockade
• Mechanism of Action: N-methyl-D-aspartate (NMDA)/glutamate receptor antagonism
• Mechanism of Action: Glutamate transporter activation

REFERENCES

• Yagupol'skii, L.M. et al., Zh. Obshch. Khim., 1963, 33, 2301, (synth)
• Eur. Pat., 1982, Pharmindustrie, 50 551; CA, 97, 44352, (pharmacol)
• Mizoule, J. et al., Neuropharmacology, 1985, 24, 767, (pharmacol)
• Tsai, C. et al., Neurol. Neurobiol., 1987, 24, 79, (pharmacol)
• Mantz, J. et al., Eur. J. Pharmacol., 1994, 257, R7, (pharmacol)
• Bensimon, G. et al., N. Engl. J. Med., 1994, 330, 585, (clin trial)
• Rowland, L.P., N. Engl. J. Med., 1994, 330, 636
• Mantz, J., CNS Drug Rev., 1996, 2, 40, (rev)