Ribavirin

• Catalog No.: Bio-0089
• CAS Number: 36791-04-5
• M. F.: C8H12N4O5
• M. W.: 244.20468

SYNONYMS

• IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
• IUPAC Traditional name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
• Synonyms: Tribavirin; VirustazCotronak; Viramid; Virazid; Ribamidil; Vilona; Viratek; Virazide; Virazole

DATABASE IDS

• CAS Number: 36791-04-5

PROPERTIES

• Application(s): Antiviral agent
• Application(s): Usually administered as an aerosol.
• Application(s): In combination with BDQ70-A , used for the treatment of malignant melanoma, Kaposi's sarcoma, warts, hairy cell leukaemia, hepatits B and C and non-Hodgkin's lymphoma
• Mechanism of Action: Inhibitor of viral RNA guanylyl transferase and (guanine-7N-)-methyl transferase enzymes

REFERENCES

• Kreishman, G.P. et al., J.A.C.S., 1972, 94, 5894, (pmr, cmr)
• Sidwell, R.W. et al., Science (Washington, D.C.), 1972, 177, 705, (pharmacol)
• Witkowski, J.T. et al., J. Med. Chem., 1973, 16, 935, (synth, pharmacol)
• Prusiner, P. et al., Nature (London), New Biol., 1973, 244, 116, (cryst struct)
• Ito, Y. et al., Tet. Lett., 1979, 2521, (synth)
• Chang, T.W. et al., Drugs, 1981, 22, 111, (rev, pharmacol)
• Canonica, P.G., Antibiotics (N.Y.), 1983, 6, 161, (rev)
• Canonica, P.G., Antiviral Res., 1985, 75, (rev)
• Smith, R.A. et al., Int. Congr. Symp. Ser. R. Soc. Med., 1986, 108, 3
• Johnson, E.M., J. Am. Coll. Toxicol., 1990, 9, 551, (tox, rev)
• Patterson, J.L. et al., Rev. Infect. Dis., 1990, 6, 1139, (rev)
• Snell, N.J.C., Antiviral Chem. Chemother., 1991, 2, 257, (rev)
• Arnold, S.D. et al., Appl. Occup. Environ. Hyg., 1991, 6, 271, (tox)
• Shults, R.A. et al., J. Occup. Environ. Med., 1996, 38, 257, (tox)
• Harvie, P. et al., J. Pharmacol. Exp. Ther., 1996, 279, 1009, (pharmacol)
• Omar, R.F. et al., Toxicol. Appl. Pharmacol., 1997, 143, 140, (tox)
• Nishimura, N. et al., Carbohydr. Res., 1998, 307, 211-215, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 626
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, RJA500