Repaglinide

• Catalog No.: Bio-0087
• CAS Number: 135062-02-1
• M. F.: C27H36N2O4
• M. W.: 452.58574

SYNONYMS

• IUPAC name: 2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
• IUPAC Traditional name: 2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
• Synonyms: NovoNorm; Prandin

DATABASE IDS

• CAS Number: 135062-02-1

PROPERTIES

• Application(s): Antihyperglycaemic agent used in the treatment of type II diabetes
• Mechanism of Action: Stimulating the release of insulin from the pancreas by closing ATP-dependent potassium channels in the membrane of the beta cells

REFERENCES

• Ger. Pat., 1987, Thomae, 3 522 604; CA, 106, 196260j, (synth)
• Eur. Pat., 1989, 147 850; CA, 104, 5651p
• Verspohl, E.J. et al., J. Pharm. Pharmacol., 1990, 42, 230, (pharmacol)
• Wolffenbuttel, B.H.R. et al., Eur. J. Clin. Pharmacol., 1993, 45, 113, (use)
• Pat. Coop. Treaty (WIPO), 1993, Thomae, 93 00 337; CA, 118, 254759q, (synth, isomers)