Raloxifene Hydrochloride

• Catalog No.: Bio-0085
• CAS Number: 82640-04-8
• M. F.: C28H30ClNO4S
• M. W.: 512.0601

SYNONYMS

• IUPAC name: 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-2,3-dihydro-1-benzothiophen-6-ol hydrochloride
• IUPAC Traditional name: 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-2,3-dihydro-1-benzothiophen-6-ol hydrochloride
• Synonyms: Evista

DATABASE IDS

• CAS Number: 82640-04-8

PROPERTIES

• Application(s): Antiestrogen
• Application(s): Prevents bone loss and reduces serum cholesterol in ovariectomized rats
• Application(s): Used in the treatment of postmenopausal osteoporosis
• Salt Data: HCl
• Mechanism of Action: Selective estrogen receptor modulator (SERM)

REFERENCES

• Wakeling, A.E. et al., J. Endocrinol., 1983, 99, 455, (pharmacol)
• Jones, C.D. et al., J. Med. Chem., 1984, 27, 1057, (synth, pharmacol)
• Wakeling, A.E. et al., J. Steroid Biochem., 1984, 20, 111, (pharmacol)
• Lindstrom, T.D. et al., Xenobiotica, 1984, 14, 841, (metab)
• Sato, M. et al., J. Bone Min. Res., 1994, 9, 715, (pharmacol)
• Black, L.J. et al., J. Clin. Invest., 1994, 93, 63, (pharmacol)
• Schmid, C.R. et al., Bioorg. Med. Chem. Lett., 1999, 9, 1137-1140, (dihydroraloxifene)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1461
• Clemett, D. et al., Drugs, 2000, 60, 379-411, (rev)