Quinapril Hydrochloride

• Catalog No.: Bio-0084
• CAS Number: 82586-55-8
• M. F.: C25H31ClN2O5
• M. W.: 474.97704

SYNONYMS

• IUPAC name: 2-(2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
• IUPAC Traditional name: 2-(2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
• Synonyms: Accuretic; Acequin; Accuprin; Accupro; Accupril; Acupril; Quinazil

DATABASE IDS

• CAS Number: 82586-55-8

PROPERTIES

• Application(s): Antihypertensive agent
• Salt Data: HCl
• Mechanism of Action: Angiotensin converting enzyme inhibitor

REFERENCES

• Klutchko, S. et al., J. Med. Chem., 1986, 29, 1953, (synth, pharmacol)
• Saynavalammi, P. et al., J. Pharmacol. Exp. Ther., 1986, 237, 246, (pharmacol)
• Hengy, H. et al., J. Liq. Chromatogr., 1988, 11, 517, (hplc)
• Kaplan, H.R. et al., Angiology, 1989, 40, 335, (tox, exp)
• Frank, G.J. et al., J. Cardiovasc. Pharmacol., 1990, 15, S14, (Quinapril)
• Wadworth, A.N. et al., Drugs, 1991, 41, 378, (rev)
• Dostal, L.A. et al., Fundam. Appl. Toxicol., 1991, 17, 684, (reprod tox)
• Materson, B.J., Am. J. Cardiol., 1992, 69, 46C, (tox)
• Zagermann, P., Pharm. Ztg., 1992, 137, 35; 39, (rev)
• Begg, E.J. et al., Br. J. Clin. Pharmacol., 1994, 37, 302, (pharmacokinet, human)
• Plosker, G.L. et al., Drugs, 1994, 48, 227, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10165, (synonyms)
• ACE Inhibitors: Current Use and Future Prospects, (Ed. Schachter, M.), M. Dunitz, 1995, (pharmacol, use, rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 938