Pravastatin Sodium

• Catalog No.: Bio-0081
• CAS Number: 81131-70-6
• M. F.: C23H35NaO7
• M. W.: 446.50957

SYNONYMS

• IUPAC name: sodium (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: sodium (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: Pravachol

DATABASE IDS

• CAS Number: 81131-70-6

PROPERTIES

• Application(s): Increases receptor-mediated catabolism of low density lipoprotein
• Application(s): Antihypercholesterolaemic agent
• Biological Source: Isol. from Absidia coerulea
• Salt Data: Na+
• Mechanism of Action: HMG CoA reductase inhibitor

REFERENCES

• Japan. Pat., 1984, Sankyo, 84 48 418; CA, 101, 28292, (isol)
• Nakaya, N. et al., Atherosclerosis (Shannon, Irel.), 1986, 61, 125, (pharmacol)
• Tsujita, Y. et al., Biochim. Biophys. Acta, 1986, 877, 50, (pharmacol)
• Haruyama, H. et al., Chem. Pharm. Bull., 1986, 34, 1459, (synth, pmr)
• Saito, Y. et al., Arzneim.-Forsch., 1988, 38, 251, (pharmacol)
• Arnold, M.E. et al., Biomed. Environ. Mass Spectrom., 1989, 18, 904, (detn)
• Singhvi, S.M. et al., Br. J. Clin. Pharmacol., 1990, 29, 239, (pharmacokinet, human)
• Lipid Management: Pravastatin and the Differential Pharmacology of HMG-CoA Reductase Inhibitors, (Ed. Wood, C.), Royal Society of Medicine, London, 1990
• Barrish, J.C. et al., Tet. Lett., 1990, 31, 2235, (synth)
• Everett, D.W. et al., Drug Metab. Dispos., 1991, 19, 740, (SQ 31906)
• McTavish, D. et al., Drugs, 1991, 42, 65, (rev)
• Serajuddin, A.T.M. et al., J. Pharm. Sci., 1991, 80, 830, (props)
• Kishida, Y. et al., Yakugaku Zasshi, 1991, 111, 800, (rev)
• Jungnickel, P.W. et al., Clin. Pharm., 1992, 11, 677, (rev)
• Zagermann, P., Pharm. Ztg., 1992, 137, 38, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 9715, (synonyms)
• Haria, M. et al., Drugs, 1997, 53, 299-336, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1277