Pemetrexed Disodium Heptahydrate

• Catalog No.: Bio-0078
• CAS Number: 357166-29-1
• M. F.: C20H33N5Na2O13
• M. W.: 597.48126

SYNONYMS

• IUPAC name: disodium (2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate heptahydrate
• IUPAC Traditional name: disodium (2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate heptahydrate
• Synonyms: Alimta

DATABASE IDS

• CAS Number: 357166-29-1

PROPERTIES

• Application(s): Antineoplastic agent
• Salt Data: 2 Na+, 7 H2O
• Mechanism of Action: Thymidylate synthase inhibitor

REFERENCES

• Taylor, E.C. et al., J. Med. Chem., 1992, 35, 4450-4454, (synth, pmr, pharmacol)
• Miwa, T. et al., J.O.C., 1993, 58, 1696-1701, (synth, ir, pmr)
• Eur. Pat., 1994, Eli Lilly, 589 720; CA, 121, 83363m, (synth)
• Hamilton, C.L. et al., J. Chromatogr., B: Biomed. Appl., 1994, 654, 297-303, (hplc)
• Rinaldi, D.A. et al., J. Clin. Oncol., 1995, 13, 2842-2850, (clin trial)
• Shih, C. et al., Cancer Res., 1997, 57, 1116-1123, (pharmacol)
• Woodland, J.M. et al., Drug Metab. Dispos., 1997, 25, 693-700, (hplc, metab)
• Calvert, A.H. et al., Br. J. Cancer, 1998, 78, 35-40, (rev)
• Graul, A. et al., Drugs of the Future, 1998, 23, 498-507, (rev)
• Taylor, E.C. et al., Tet. Lett., 1999, 40, 4023-4026, (synth)