Paclitaxel

• Catalog No.: Bio-0076
• CAS Number: 33069-62-4
• M. F.: C47H51NO14
• M. W.: 853.90614

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• Synonyms: Taxol A; Yewtaxan; Anzatax

DATABASE IDS

• CAS Number: 33069-62-4

PROPERTIES

• Application(s): Antileukaemic and antineoplastic agent, esp. against melanoma and ovarian tumours
• Application(s): Use limited by low solubility and scarce availability of Taxus brevifolia bark
• Application(s): Biochemical tool extensively used to study cellular shape and function.
• Application(s): Also shown to be active against oomycete fungi
• Biological Source: Isol. from the stem bark of Taxus brevifolia and Taxus cuspidata (Taxaceae)
• Mechanism of Action: Interferes with the normal function of microtubule growth by hyper-stabilisation of their structure
• Mechanism of Action: Binds to the beta subunit of tubulin

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