Ornidazole

• Catalog No.: Bio-0074
• CAS Number: 16773-42-5
• M. F.: C7H10ClN3O3
• M. W.: 219.6256

SYNONYMS

• IUPAC name: 1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
• IUPAC Traditional name: 1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
• Synonyms: Tinerol; Madelen; Ornidal; Kolpicid; Tiberal; Betiral; Biteral; Danubial; Tibal

DATABASE IDS

• CAS Number: 16773-42-5

PROPERTIES

• Application(s): Antiprotozoal agent
• Application(s): Active against anaerobic bacteria
• Mechanism of Action: Interacts with DNA to cause a loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis and cell death in susceptible organisms

REFERENCES

• Hoffer, M. et al., J. Med. Chem., 1974, 17, 1019, (synth, pharmacol)
• Nagarajan, K. et al., Indian J. Chem., Sect. B, 1982, 21, 1006, (cmr, pmr, uv, ms)
• Chen, B.C. et al., Helv. Chim. Acta, 1983, 66, 1537, (N-15 nmr)
• McClain, R.M. et al., Toxicol. Appl. Pharmacol., 1988, 92, 488, (tox)
• Yeung, C.H. et al., J. Reprod. Fertil., 1995, 103, 257; 1996, 106, 231, (tox)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 626
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, OJS000