Orlistat (Tetrahydro)

• Catalog No.: Bio-0073
• CAS Number: 96829-58-2
• M. F.: C29H55NO4
• M. W.: 481.7513

SYNONYMS

• IUPAC name: (2S)-1-[(2S,3R)-3-hexyloxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
• IUPAC Traditional name: (2S)-1-[(2S,3R)-3-hexyloxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
• Synonyms: Tetrahydrolipstatin; Orlipastat

DATABASE IDS

• CAS Number: 96829-58-2

PROPERTIES

• Application(s): Used to treat obesity
• Mechanism of Action: Pancreatic lipase inhibitor

REFERENCES

• Barbier, P. et al., Helv. Chim. Acta, 1987, 70, 196, (synth, abs config)
• Hogan, S. et al., Int. J. Obes., 1987, 11, 35, (pharmacol, deriv)
• Kupfer, E. et al., J. Antibiot., 1987, 40, 1081; 1086, (isol, struct, props)
• Hadvry, P. et al., Biochem. J., 1988, 256, 357, (pharmacol)
• Barbier, P. et al., J.O.C., 1988, 53, 1218, (synth, deriv, bibl)
• Fleming, I. et al., Tet. Lett., 1990, 31, 3645, (synth)
• Chadha, N.K. et al., J.O.C., 1991, 56, 4714, (synth)
• Hauptman, J.B. et al., Am. J. Clin. Nutr., 1992, 55, Suppl; 309S, (Orlipastat, pharmacol, human)
• Lthi-Peng, Q. et al., Eur. J. Biochem., 1992, 205, 383, (Orlipastat, pharmacol)
• Stalder, H. et al., Helv. Chim. Acta, 1992, 75, 1593, (Tetrahydrolipstatin, metab)
• Pommier, A. et al., Synthesis, 1994, 1294, (Tetrahydrolipstatin, synth)
• Pommier, A. et al., J.O.C., 1995, 60, 7334, (synth, bibl, pmr, cmr)
• McNeely, W. et al., Drugs, 1998, 56, 241-249, (rev)
• Ghosh, A.K. et al., Chem. Comm., 1999, 1743-1744, (synth, Tetrahydrolipstatin)
• Harp, J.B., Drugs of Today (Barcelona), 1999, 35, 139-145
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1611
• Keating, G.M. et al., Drugs, 2001, 61, 2107-2119, (orlistat, rev)
• Goese, M. et al., J.O.C., 2001, 66, 4673-4678; 2002, 67, 2257-2262, (biosynth)