Olopatadine Hydrochloride

• Catalog No.: Bio-0072
• CAS Number: 140462-76-6
• M. F.: C21H24ClNO3
• M. W.: 373.87316

SYNONYMS

• IUPAC name: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• IUPAC Traditional name: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• Synonyms: Patanase; Opatanol; Patanol; Pataday; Patanol S

DATABASE IDS

• CAS Number: 140462-76-6

PROPERTIES

• Application(s): Antiallergic agent
• Application(s): Used in the treatment of allergic rhinitis, urticaria, allergic conjunctivitis and asthma
• Salt Data: HCl
• Mechanism of Action: Histamine H1-receptor antagonist,
• Mechanism of Action: Mediator release inhibitor

REFERENCES

• Eur. Pat., 1987, Kyowa Hakko Kogyo, 235 796; CA, 108, 167330, (synth, pharmacol)
• Oshima, E. et al., J. Med. Chem., 1992, 35, 2074, (synth, cryst struct, pharmacol)
• Ikeda, K. et al., Int. Arch. Allergy Appl. Immunol., 1995, 106, 157, (pharmacol)
• Ikemura, T. et al., Int. Arch. Allergy Appl. Immunol., 1996, 110, 57; 64, (pharmacol)
• Sharif, N.A. et al., J. Pharmacol. Exp. Ther., 1996, 278, 1252, (pharmacol)
• Berdy, G.J. et al., Clin. Ther., 2000, 22, 826-833; 2001, 23, 1272-1280, (pharmacol)