Nilutamide

• Catalog No.: Bio-0070
• CAS Number: 63612-50-0
• M. F.: C12H10F3N3O4
• M. W.: 317.2207096

SYNONYMS

• IUPAC name: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
• IUPAC Traditional name: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
• Synonyms: Nilandron; Anandron

DATABASE IDS

• CAS Number: 63612-50-0

PROPERTIES

• Application(s): Antineoplastic agent
• Application(s): Used for treatment of prostatic cancer
• Mechanism of Action: Androgen receptor blocker, preventing its interaction with testosterone

REFERENCES

• Ger. Pat., 1977, Roussel, 2 649 925; CA, 87, 85005, (synth)
• Raynaud, J.P. et al., Prog. Clin. Biol. Res., 1985, 185A, 99, (rev, pharmacol)
• Ojasoo, T., Drugs of the Future, 1987, 12, 763, (rev)
• Moguilewsky, M. et al., J. Steroid Biochem., 1987, 27, 871, (rev, pharmacol)
• Pendyala, L. et al., Cancer Chemother. Pharmacol., 1988, 22, 69, (metab)
• Moguilewsky, M. et al., Prog. Cancer Res. Ther., 1988, 35, 349, (rev, activity)
• Dhar, J.D. et al., Contraception, 1990, 42, 121, (tox)
• Decensi, A. et al., Eur. J. Cancer, 1991, 27, 1100, (clin trial)
• Gomez, J.-L. et al., Am. J. Med., 1992, 92, 563, (tox)
• Harris, M.G. et al., Drugs Aging, 1993, 3, 9, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 496
• Berson, A. et al., J. Pharmacol. Exp. Ther., 1994, 270, 167, (tox)