Nicergoline

• Catalog No.: Bio-0069
• CAS Number: 27848-84-6
• M. F.: C24H26BrN3O3
• M. W.: 484.38554

SYNONYMS

• IUPAC name: [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^2,^7.0^1^2,^1^6]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
• IUPAC Traditional name: [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^2,^7.0^1^2,^1^6]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
• Synonyms: Sermion; Nicotergoline; Nimergoline; Nargoline

DATABASE IDS

• CAS Number: 27848-84-6

PROPERTIES

• Application(s): Cerebroprotective props
• Application(s): Has been used in treatment of senile dementia
• Mechanism of Action: Cholinergic
• Mechanism of Action: Peripheral vasodilator
• Mechanism of Action: a1-Adrenoceptor antagonist
• Mechanism of Action: Calcium channel antagonist

REFERENCES

• Arcari, G. et al., Experientia, 1972, 28, 819
• Bernardi, L. et al., Farmaco, Ed. Sci., 1975, 30, 789, (synth, pharmacol)
• Neumann, B.W. et al., Arzneim.-Forsch., 1979, 29, 1206, (numerous papers)
• Arrigo, A. et al., Int. J. Clin. Pharmacol. Res., Suppl. 1, 1982, 11, 33, (use)
• Shintomi, K. et al., J. Pharmacobio-Dyn., 1987, 10, 35, (pharmacol, tox)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7056, (synonyms)
• Takahashi, K. et al., Br. J. Pharmacol., 1990, 100, 705, (pharmacol)
• Banno, K. et al., J. Chromatogr., 1991, 568, 375, (hplc)
• Sioufi, A. et al., Biomed. Chromatogr., 1992, 6, 9, (hplc, metab)
• Fumagalli, M. et al., Contact Dermatitis, 1992, 27, 256
• Carfagna, N. et al., Neurosci. Lett., 1995, 197, 195, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1731
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, NDM000